The Queen of the Damned - Anne Rice (Book 3 in the Vampire Chronicles)

After 6,000 years of horrifying stillness, Akasha, mother of all vampires and Queen of the Damned, has risen from her sleep to let loose the powers of the night. But her monstrous plan for ruling the worlds of the living and the undead must be stopped before she destroys mankind, and it falls to the vampire Lestat to fight her all-encompassing evil - for it is he who challenged her power by waking her from sleep.